12/16/2023 0 Comments Transient global amnesia frequency![]() Lifestyle activity and dietary habits exhibit normal fluctuations with additional background health impacts. 15, 16, 17, 18 These alterations are thought to follow meteorological seasonal changes such as air pollution, UV radiation, temperature, and atmospheric air pressure. Significant alterations in physiological parameters have been previously noted to alternate during the seasons, including hormonal changes, production of coagulation factors, oxidative stress, endothelial dysfunction, mild changes in hemodynamic parameters, immunological changes, and susceptibility to infectious agents. This observation may help to improve the understanding of the pathophysiology underlying this condition. We have observed that the incidence of TGA exhibits both monthly and seasonal peaks, with these results being confirmed via logistic regression and time-season analysis. Our study investigated a relatively large number of subjects over a long duration. We have retrospectively analyzed seasonal patterns in the incidence of TGA at a tertiary medical center over a 15-year period. We used Fourier transformation implemented using SPSS software to calculate the intensity. We have also performed a time series analysis through a spectral density, and presented the data as a periodogram, since such plots may be used to identify dominant periods of time series. Summer was used as the reference category for the seasonal analysis, while the month of June was used for the monthly analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated as estimates of relative risk. Since the outcome variable was binary, a logistic regression was fitted to the data, with month or season as a categorical dependent variable. The methods considered range from a comparison of disease incidence (percentage of TGA hospitalizations relative to the total number of hospitalizations) between the extremes of summer and winter, through modeling of the intensity of seasonal patterns by use of a periodogram, to more-advanced generalized linear models. Statistical methods for the assessment and quantification of seasonality were chosen based on an extensive review 14 and our previous experience. For this analysis, hospitalization data were grouped into seasons defined according to the Gregorian calendar. Our statistical hypotheses were that the incidence of TGA varies with the month or season. Our initial review confirmed that this observation is indeed valid and encouraged us to further assess the epidemiology of TGA admissions over a 15-year period. We therefore decided to analyze whether this phenomenon is consistent for admissions in the internal medicine wing of the entire hospital over several years. Moreover, we noted that most admissions with TGA to the neurology department occurred during winter and spring. ![]() We noted that patients hospitalized with TGA tend to appear in clusters. 12Įvery patient with an acute presentation of isolated amnesia in our medical center is admitted for further observation and evaluation. 6 There is evidence that TGA is correlated with transient ischemic attacks (TIAs), 7, 8 venous congestion, 9, 10 and a migrainous phenomenon, 11 but definitive proof supporting any of these mechanisms is lacking. 4 The incidence of TGA is approximately 20 per 100,000 persons among those aged 50–80 years. 3 Case series in which diffusion-weighted imaging (DWI) was performed on TGA patients revealed focal areas of restricted diffusion, confined to the CA1 area of the hippocampus. ![]() 1, 2 It is thought to be benign, although slight memory deficits might persist for months after an episode. Transient global amnesia (TGA) is an intriguing clinical condition hallmarked by the sudden onset of deficit in anterograde memory that usually resolves over a day. ![]()
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